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SalixinŽ

Composition:

Each caplet contains standardized extract of
Willow bark (Salix spp.) ............ 500 mg
(Correspond to 75 mg salicin)

Pharmacological Actions:

Willow bark contains a group of phenolic glycosides mainly salicortin and salicin. Salicortin is hydrolysed in the small intestines into salicin and its esters which are further hydrolysed into saligenin and glucose. In contrast to aspirin, also known as acetyl salicylic acid, both salicortin and salicin have no effect on gastric mucosa and therefore there is no chance of gastric irritation or erosion and thus no risk of bleeding from the GI tract. Saligenin is then absorbed via terminal ileum and oxidized to salicylic acid in the liver and blood. Salicylic acids reduce prostaglandin levels in body tissue through an inhibition of PGH-synthase in inflamed tissues (COX-2) and are predominantly used for their anti-inflammatory and analgesic properties. Again in contrast to aspirin, it has no effect on platelet (i.e. no antiplatelet action) because of the lack of acetyl group in its molecular structure, and thus it gives no chance of bleeding from blood vessels.

Indications:

* Headache, muscle pain, joint pain, arthritis, common cold and fever.

Side effects: None.

Drug interaction:

NSAIDS, alcohol and barbiturates may mask the symptoms of salicylate over dose.

Contraindications:

Aspirin sensitive patients, Children with viral infection such as chicken pox, asthmatics and diabetic patients.

Dosage:

One tablet two times daily after meal or as directed by physician.

How supply:

10 tablets in one blister. Three blisters per box.