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Milk Thistle

The best liver support

Composition:

Each tablet contains

Pharmacological actions:

The therapeutic efficacy is based on several separate mechanisms of action.

1. Hepatoprotective effects
Silymarin's ability to protect liver destruction and enhance liver fuction is due largely to its inhibition of the factors that are responsible for hepatic damage, i.e.free radicals and leukotrienes, coupled with its ability to stimulate liver protein synthesis. Silymarin components prevent free radical damage by acting as antioxidants .Silymarin is many times more potent in antioxidant activity than vitamin E. Unlike most flavonoid antioxidants, silymarin does not remain in the plasma and mainly an affinity for liver.

2. Enhance hepatic glutathione activity
Glutathione is one of the most important antioxidant molecules for elimination of cytotoxicity in human. Silymarin's affinity for liver tissue has been shown to substitute for depleted glutathione in hepatocytes. Even in normal it increases the basal GSH level of the liver by 35% over control.

3. Prevent lipid peroxidation in hepatocyte
Free radical damage of lipids in a cell membrane is known as lipid peroxidation. This process is prevented by silymarin allowing membrane stability.This mechanism is thought to be primary mode of action in hepatoprotection and keeps amatoxins out of hepatocytes in mushroom poisoning and other form of liver poisoning.

4. Stimulation of hepatic protein synthesis and liver cells regeneration
Silymarin promotes regeneration of liver cells by involving the cell's DNA. The polymerase A specifically promotes nucleus and heads out into the cytoplasm where it hooks up with the endoplasmic reticulum to do new protein synthesis .

5. Anti-inflammatory effects
Silymarin has been shown to be a potent inhibitor of lipoxygenase enzyme. Silymarin has also shown to inhibit prostraglandin synthesis during inflammation. Silymarin counteracts this deleterious process by suppressing the pathological decomposition of membrane lipids and inhibits prostaglandin formation. As leukotrienes and prostagladins are also involved in the damage of the liver by toxins, their neutralization by silybin is another mechanism for its protection of the liver.

Bioavailability:

Previously, oral administration of silybin has been limited by bioavailability. Our product is a conjugate form of silymarin with phosphotidylcholine from the soy bean and is much more lipophilic (90% absorption) than silymarin alone.

Indications:

• Toxic liver damage caused by alcohol, psychopharmaceuticals and chemicals.
• Mushroom poisoning
• Fatty liver
• Cirrhosis of liver
• Chronic hepatitis

Side effects:

Numerous studies on silymarin has shown it is virtually without side effects when used in therapeutic doses. There have been isolated reports of a mild laxative effect. Toxicity studies show virtually no damage to any body tissues. It is not cross-react with any medications, and no contraindications are known.

Dosage:

One tablet two times daily before meal. The dose can be double in case of severe liver detoxication, and cirrhosis of liver because silymarin is not found to be toxic.

How Supply:

30 tablets in one bottle.